Kau Lab publications


The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

Naomi G. Wilson, Ariel Hernandez-Leyva, Drew J. Schwartz, Leonard B. Bacharier, Andrew L. Kau*

Pubmed/PDF

FEMS Microbes, March 2024

Secretory leukocyte protease inhibitor protects against severe urinary tract infection

Anne L. Rosen, Michael A. Lint, Dayne H. Voelker, Nicole M. Gilbert, Christopher P. Tomera, Jesús Santiago-Borges, Meghan A. Wallace, Thomas J. Hannan, Carey-Ann D. Burnham, Scott J. Hultgren, Andrew L. Kau*

Pubmed/PDF

mBio, January 2024


Developmental Progression of the nasopharyngeal microbiome during childhood and association with the lower airway

Ariel Hernandez-Leyva, Anne L. Rosen, Christopher P. Tomera, Elaina E. Lin, Elikplim H. Akaho, Allison M. Blatz, William R. Otto, Joey Logan, Lisa R. Young, Andrew L. Kau*, Audrey R. Odom John*

medRxiv PDF

(in review), September 2023

The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

Naomi G. Wilson#, Ariel Hernandez-Leyva#, Anne L. Rosen, Natalia Jaeger, Ryan T. McDonough, Jesus Santiago-Borges, Michael A. Lint, Thomas R. Rosen, Christopher P. Tomera, Leonard B. Bacharier, S. Joshua Swamidass, Andrew L. Kau*

Pubmed/PDF

iScience, January 2023

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Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

Natalia Jaeger, Ryan T. McDonough, Anne L. Rosen, Ariel Hernandez-Leyva, Naomi G. Wilson, Michael A. Lint, Emilie V. Russler-Germain, Jiani N. Chai, Leonard B. Bacharier, Chyi-song Hseih, Andrew L. Kau*

Pubmed/PDF

Cell Reports, November 2020


Reviews

Can Therapeutic Targeting of the Human Microbiome Influence Asthma Management? A Pro/Con Debate

Andrew L. Kau, Anne L. Rosen, Christian Rosas-Salazar

Pubmed/PDF

Journal of Allergy and Clinical Immunology: In Practice, January 2024

The Abcs of wheeze: asthma and bacterial communities

Naomi G. Wilson, Ariel Hernandez-Leyva, Andrew L. Kau

Pubmed/PDF

PLoS Pathogen, April 2019

Breathe soft, through early windows break

Ariel Hernandez-Leyva, Naomi G. Wilson, Andrew L. Kau

Pubmed/PDF

Cell Host and Microbe, September 2018


Collaborations

gut microbiota and microbiota-derived metabolites promotes endometriosis

Sangappa B. Chadchan, Sumanta K. Naik, Pooja Popli, Chandni Talwar, Satwikreddy Putluri, Chandrasekhar R. Ambati, Michael A. Lint, Andrew L. Kau, Christina L. Stallings, Ramakrishna Kommagani

Cell Death Discovery, 2023

Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses

Guy Hazan, Anna Eubanks, Carrie Gierasch, Jeffrey Atkinson, Carolyn Fox, Ariel Hernandez-Leyva, Anne L. Rosen, Andrew L. Kau, Eugene Agapov, Jennifer Alexander-Brett, Deborah Steinberg, Diane Kelley, Michael White, Derek Byers, Kangyun Wu, Shamus P. Keeler, Yong Zhang, Jeffrey R. Koenitzer, Elise Eiden, Neil Anderson, Michael J. Holtzman, Jeffrey Haspel

Journal of Immunology, 2022

Altered IgA Response to Gut Bacteria Is Associated with Childhood Asthma in Peru

Chyi-Song Hsieh, Sunaina Rengarajan, Andrew L. Kau, Carla Tarazona-Meza, Andrew Nicholson, William Checkley, Karina Romero, Nadia N. Hansel

Journal of Immunology, 2021


Previous Works

Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice

Planer JD, Peng Y, Kau AL, Blanton LV, Ndao IM, Tarr PI, Warner BB, Gordon JI

Nature, 2016

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI

Science Translational Medicine, 2015

Human nutrition, the gut microbiome and the immune system

Kau AL*, Ahern PP*, Griffin NW, Goodman AL, Gordon JI

Nature, 2011

Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice

Kau AL, Martin SM, Lyon W, Hayes E, Caparon MG, Hultgren SJ

Infection and Immunity, 2005

Interaction of uropathogenic Escherichia coli with host uroepithelium

Kau AL, Hunstad DA, Hultgren SJ

Current Opinion in Microbiology, 2005